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In the present work, we demonstrated for the first time that RAR and RXR subtypes were expressed in rat synovial fibroblasts at either the mRNA or the protein level. All receptor subtypes, except RXR-γ, were detected and this was consistent with the recent demonstration that their mRNAs, except the RXR-γ mRNA, were expressed in human osteoarthritic chondrocytes [25]. In response to IL-1 stimulation, the expression of all RAR subtypes decreased in synovial fibroblasts, whereas those of RXR-α and RXR-β remained unaffected. However, such inhibitory effect of IL-1 may be counterbalanced in the presence of RAR agonist since all RAR subtypes contain a retinoic acid response element (RARE) in their promoter region [26], which renders them highly inducible by these agonists. In our experimental conditions, we observed that ATRA induced a threefold increase in RAR mRNA levels in IL-1-stimulated cells (data not shown), therefore suggesting that our biological system was suitable to study the pharmacological properties of agonists of RAR or RXR subtypes.

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The flight from Germany to Egypt was operated with a combination of 34% sustainable aviation fuel (SAF) to encourage decarbonization in aviation. This isn't the first time Egyptair had taken flight using SAF, as reported by Simple Flying last year when MS800 operated from Paris Charles de Gaulle (CDG) to Sharm el Shiekh (SSH).

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